Tumor microenvironments are dynamic and complex: they are composed of multiple cell types, chemical gradients, and extracellular matrix components,. The stiffness of the extracellular matrix also regulates tumor behavior,,. Novel discoveries in cancer biology and treatment will require researchers to use tools that help create relevant and predictive models to uncover new mechanisms and therapies.
2D cultures poorly represent tumor microenvironments and limit cellular mechanisms that can be targeted in drug discovery. Cancer cells propagated in 2D:
Consequently, therapeutics that target cell-cell communication and interaction, cell-matrix interactions, adhesion, extravasation, and migration may be overlooked while therapeutics that target cell proliferation may appear artificially promising.
Cell-cell interactions, extracellular matrix components, chemical gradients, growth rates, and gene expression in 3D have been shown to provide more clinical relevance compared to cells in 2D culture,.
Cell-Mate3DTM Has Advantages Over Other 3D Options Because It:
Researchers benefit because Cell-Mate3D is: