About Cell-Mate 3D

Mouse Injection in Cell-Mate3D Cell Culture Process
Cell Culture Process Matrix

Cell-Mate3D™

 

Cell-Mate3D™ is an injectable, tissue-like matrix that offers researchers a biologically relevant microenvironment for in vitro and in vivo biomedical research. It is chemically defined: composed of naturally occurring biopolymers Hyaluronic Acid (HA) and Chitosan (CT).

 

  • HA is a linear polysaccharide found in the extracellular matrix of connective, epithelial, and neural tissues. It is involved in cell proliferation, migration, embryonic development, and wound healing. HA also plays a role in cancer biology.
  • CT, derived from Chitin, is a positively charged polysaccharide that is found in the exoskeleton of crustaceans.

 

When Cell-Mate3D™ dry blend is combined with cells in hydration fluid, Cell-Mate3D™ matrix forms instantly through electrostatic interactions between HACOO groups and CTNH3+ groups. This interaction results in Poly-Electrolytic-Complex fibers that give structure to the construct.

3D Fast: Embedding Cells into Cell-Mate3D™

Animal Cell Embedding in Cell Culture Process

Advance your research with Cell-Mate3D™

  • Tissue-like stiffness better mimics in vivo extracellular environment
  • Can allow for emergence of complex 3D structures/micro-tissues
  • Cells may secrete own extracellular matrix into construct over time

Advantages of Cell-Mate3D™ over other 3D Culture options

  • Permits long-term 3D cultures without producing a necrotic core
  • No cytotoxic chemical or UV crosslinking required
  • Chemically defined
  • Use both in vitro and in vivo (injectable)
  • Cells distributed throughout the matrix

Analyze your Cell-Mate3D™ cultures using common laboratory techniques