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Beyond Spheroids. Creating a Better 3D Cell Culture Platform.

Dr. John Brekke founded BRTI Life Sciences in 2003 with a mission to create matrix technologies for biomedical researchers that are “biologically relevant, defined, tissue-like, translational, and free from chemical or UV crosslinking reagents”. The result is Cell-Mate3D, an injectable matrix and 3D cell culture tool that creates an ideal microenvironment for cell and drug delivery, disease modeling, and regenerative engineering applications.

The company has grown to include leaders in science and industry and continues to offer easy to use, high quality solutions that help scientists succeed. We are continually inspired by our customer’s ideas, discoveries and dedication. Aiming to provide customers with products that truly add value to their research, we guarantee complete customer satisfaction with every purchase.

John Brekke

Our Founder

John Brekke, D.D.S.

Following completion of his residency at Washington Hospital Center in 1971, Dr. Brekke engaged in private practice of oral and maxillofacial surgery while developing a synthetic, biodegradable bone graft substitute. This technology was purchased by Kensey Nash Corporation in 2000. Dr. Brekke founded Bioactive Regenerative Therapeutics, Inc. in 2003, to develop a tissue-like, biomimetic, 3D, cell culture matrix based on hylauronan and chitosan, now known as Cell-Mate3D™. He continues study of cellular responses to mechanical properties of their 3D microenvironments and use of these matrices as cell delivery platforms.

Dr. Brekke was appointed the McKnight Distinguished Visiting Professor in the Department of Chemical Engineering, University of Minnesota Duluth, for academic years 2007 – 2009. He taught chemical theory of biomimetic materials and their practical applications to research tools and therapeutic devices in a course entitled Biomimetic Formulations. Dr. Brekke has authored numerous patents and journal publications in the fields of Tissue Engineering and Regenerative Medicine.

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