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Apoptosis, or programmed cell death, is an important cellular mechanism that is critical in development and tissue homeostasis.  Apoptosis also plays a role in cancer biology.  For example, visualizing apoptosis in response to treatments is one way to characterize potential therapies. While 3D cell cultures are ideal...

Abstract: Tissue organoids are a promising technology that may accelerate development of the societal and NIH mandate for precision medicine. Here we describe a robust and simple method for generating cerebral organoids (cOrgs) from human pluripotent stem cells by using a chemically defined hydrogel material...

BRTI Life Sciences' unique 3D matrix will be included in a study at the University of Minnesota of immunoisolated islets in a structured biomimetic environment to treat insulin-dependent diabetes. The study, which is fully funded by the Juvenile Diabetes Research Foundation (JDRF), employs a device, including islets...

Podium Presentation: Induction of Cerebral Organoids from Human Induced Pluripotent Stem Cells using a Chemically Defined Hydrogel and Defined Culture Medium. Timothy D. O'Brien https://www.regenerativemedicineworkshop.com/users/timothy-d-obrien Poster Presentation: Culture and Trilineage Differentiation of hMSCs Within a Novel 3D Microenvironment. Applications for in vitro and in vivo Biomedical Research. Beth A. Lindborg, Yi Wen Chai, Connor B....

"A chitosan-hyaluronan based hydrogel-hydrocolloid supports in vitro culture and differentiation of human mesenchymal stem/stromal cells (MSCs)" was recently accepted in Tissue Engineering Part A.  This article describes how Cell-Mate3D can improve differentiation potential and induce more complex structures compared to 2D cultures. Click here for the abstract....