Instron – Application Challenges – Hydrogels are Hard to Hold

Instron – Application Challenges – Hydrogels are Hard to Hold

Jiggly, water-soluble monomers are excellent candidates for cell culture, stem cell differentiation, cancer cell research, wound healing, drug delivery, tissue engineering, and medical device development. And, just like all new materials, it must be well characterized in order to trust results and develop new products … But we all know that gripping a jello-like substance is a challenge.

Dr. John H. Brekke – a pioneer in the fields of tissue engineering and regenerative medicine – established BRTI Life Sciences in 2003. His mission is to create matrix technologies for biomedical researchers that are “biologically relevant, defined, tissue-like, translational, and free from chemical or UV crosslinking reagents”. As a result of his mission, the firm has developed a unique, biomimetic hydrogel intended as a three-dimensional environment for study of stem cells and their therapeutic applications. Cell-Mate3D, a biomimetic 3D cell culture matrix, is designed to support and enhance cell culture assays. The materials are carefully chosen and processed to create an ideal microenvironment for your cells.

In a recent collaboration with Dr. John Brekke, we have had the opportunity to create a new zero-clamp grip compatible with our bioreactor chamber and frames for tension characterization and stimulation of hydrogels. This instrumentation and mechanical environment allows for Dr. Brekke to test and tune the stiffness of their product. Tissue-like stiffness mimics the in vivo extracellular environment and resulting mechanical signals influence cell behavior and differentiation potential. BRTI plans to supply Cell-Mate3D in a variety of stiffness’s, from which customers will be able to choose the correct micro-environment for their specific research.

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